Trauma-hemorrhage and dendritic cell functions: a critical review of splenic dendritic cell dysfunction following trauma-hemorrhage and therapeutic approach
نویسندگان
چکیده
Abstract Introduction Many studies demonstrated that trauma-hemorrhage induces marked alterations in various immune functions. The trauma-hemorrhage-induced immunosuppression is associated with an increased susceptibility to subsequent sepsis, organ failure and mortality. Previous studies demonstrated that trauma-hemorrhage induces immunosuppression in both innate immune systems and adaptive immune systems. Dendritic cell is the most potent antigen-presenting cell that initiates innate and adaptive immune response. The aim of this review was to discuss trauma-hemorrhage and dendritic cell functions. Conclusion Trauma-hemorrhage impairs splenic dendritic cell maturation. Suppressed TLR4 expression and MAPK activation contribute to the hyporesponsiveness of splenic dendritic cells following trauma-hemorrhage. 17β-oestradiol produces immunoprotective effects on splenic dendritic cells following trauma-hemorrhage. The immunomodulatory properties of 17β-oestradiol might be a potent therapeutic strategy for the treatment of depressed splenic dendritic cell functions following trauma-hemorrhage.
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